Three people have died and a further five people have been infected in an outbreak of Hantavirus on the Dutch cruise ship MV Hondius, according to a press release issued by the World Health Organization on 8 May 2026. The disease, which is caused by the Virus Orthohantavirus andesense, is a zoonotic disease (disease with a reserve in a wild Animal population which sometimes spreads to Humans) causing a hemorrhagic or pulmonary fever. It is not easily passed from Human-to-Human, but can do so when people are living together in close conditions in an environment such as a cruise ship.
The outbreak is thought to have begun with an 70-year-old male Dutch national who boarded the ship at Ushuaia, on the Argentinian part of Tierra del Fuego, on 1 April 2026, after spending three months touring Argentina, Chile, and Uruguay. This patient developed symptoms at sea, and died on 11 April before the ship reached any port. He is considered a probable case, as no microbiological tests were carried out.
The second patient to develop the disease was the original patient's 69-year-old widow, who had been travelling with the first patient and joined the ship with him. She developed gastrointestinal symptoms at sea, and left the ship when it arrived at Saint Helena on 24 April, and flew to Johannesburg the following day, where she boarded a flight to Amsterdam, where her condition deteriorated rapidly, causing her to be removed from the plane and moved to a local hospital, where she died on 26 April. She was confirmed as being infected with Orthohantavirus andesense by polymerise chain reaction testing carried out by the South African National Institute for Communicable Diseases.
The third patient, another adult male, started to show symptoms on 24 April, and was evacuated from the ship when it put into Ascension Island on 27 April. This patient was also airlifted to Johannesburg, where he is being treated in an intensive care unit. This patient was also confirmed as being infected with Orthohantavirus andesense by polymerise chain reaction testing.
A fourth patient, and adult female German national, developed a fever on 28 April, while the ship was sailing between Ascension Island and the Cape Verde islands, and died of pneumonia on 2 May, before the ship made it to port. This patient was later confirmed to have died of Hantavirus by post-mortem examination.
The fifth patient, the ship's doctor, began to develop symptoms on 30 April, and was confirmed as having Hantavirus by polymerise chain reaction testing when the ship reached Cape Verde on 6 May, and was airlifted to the Netherlands, where he is currently being treated in an isolation unit.
The sixth patient, a guide employed on the ship, reported mild respiratory and gastrointestinal symptoms on 27 April. He was also diagnosed with Hantavirus infection by polymerise chain reaction testing when the ship reached Cape Verde and airlifted to the Netherlands.
A seventh patient, who disembarked from the ship at St Helena on 22 April and flew home to Switzerland via South Africa and Qatar, began to show symptoms on 1 May. He immediately self-reported to medical authorities in Switzerland, and is now being treated in an isolation unit there.
An eighth patient, who disembarked from the ship at Tristan da Cunha in the South Atlantic on 14 April, began to show symptoms on 28 April. He is now being treated in isolation, although results of testing for the Virus have yet to be returned.
A ninth patient with Hantavirus-like symptoms was evacuated at Cape Verde and airlifted to Germany, but was later found not to be infected. Efforts are still being made to trace 32 other patients who disembarked at Saint Helena and dispersed to a variety of countries before the nature of the outbreak was understood. After leaving Cape Verde the ship sailed to the Canary Islands, where it was met by medical personnel from the World Health Organization and a variety of countries, where both passengers and crew were screened for the Virus before being allowed to travel on to their home countries, where they will be required to undergo a period of isolation. A skeleton crew and medical personnel remained on the ship while it was sailed to the Netherlands to be thoroughly disinfected.
A flight attendant on the Johannesburg-Amsterdam flight from which the second patient was removed also later developed symptoms, and was admitted to a hospital in Amsterdam. Two Singaporean nationals who had been on the ship and subsequent flight from Saint Helena to Johannesburg were tested for the Virus after one developed Hantavirus-like symptoms, but neither was found to be infected. Attempts are still being made to trace passengers from both fights.
Hantavirus infections are caused by triple single-stranded negative-sense RNA Viruses of the genus Orthohantavirus. These Viruses are typically found in Rodents, with 28 species known, each of which infects a different species of Rodent. These Viruses occasionally jump species and infect Humans, where they break down into two groups, Old World Hantaviruses, which can cause a hemorrhagic fever accompanied by a severe kidney infection, and New World Hantaviruses, which cause a severe respiratory disease.
Structure of the Andes Hantavirus. Lexi Schoonover/Hope College/Wikimedia Commons.
The Andes Hantavirus, Orthohantavirus andesense, is found in Long-tailed Pygmy Rice Rats, Oligoryzomys longicaudatus, a wild Rodent found in the southern Andes of Chile and Argentina, where it does not appear to produce any symptoms. It can be transmitted to Humans through the inhalation of aerosols that contain rodent saliva, urine, or feces, through the consumption of contaminated food, or by being bitten or scratched by a Rat.
There is no effective treatment or vaccine for Hantavirus, and the disease is best prevented by using cleanliness and good hygiene to keep Rodents from entering Human dwellings or workplaces. If this fails a pest control consultant should be used to remove the Rodents. Placing infected patients in intensive care with fluids and, if necessary, artificial respiration, can help, but even with these precautions about 30% of patients typically die. Patients who have been infected with the disease and survive are generally immune to further infections with the same Virus.
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