Showing posts with label Chlamydiae. Show all posts
Showing posts with label Chlamydiae. Show all posts

Sunday, 6 September 2026

Trachoma eliminated in Timor-Leste.

The elimination of Trachoma, a transmissible Bacterial disease which is thew world's leading infectious cause of blindness, in Timor-Leste (East Timor) has been confirmed by the World Health Organization, according to a press release issued on 3 September 2026. This conformation also marks the elimination of Trachoma across the Southeast Asia Region, with all other countries in that region either having previously eliminated the disease or never having suffered from it. The conformation is therefore a significant step on the way to the World Health Organization's goal of eliminating the disease worldwide by 2030.

The flag of Timor-Leste. Isabel Nolasco/Wikimedia Commons.

The announcement is the result of a campaign of screening which began on Atauro Island in 2015, and which has been rolled out to every region of the country. In 2025, a total of 4949 children aged 0-5 in all 13 municipalities of Timor-Leste did not find a single case of Trachoma, leading to the conclusion that the disease had been eliminated. The country does, however, plan to continue to monitor for Trachoma, and retain the ability to treat the disease.

Trachoma is caused by the Bacterium Chlamydia trachomatis, and spread through contact with mucus emitted from the eyes and nose during infection, and can be spread by Flies. Infections are most common among children, and the disease can spread rapidly in overcrowded environments, particularly where sanitation is poor and access to clean water is limited. The Bacterium infects the inside of the eyelid, causing a roughening which can in turn lead to damage to the surface of the eye. Eventually the disease can lead to the eyelids turning inwards, blinding the patient. Infections are generally fought off fairly quickly, particularly in adults, but having been infected does not offer protection against future infections, and the damage caused by each infection is cumulative. Chlamydia trachomatis is vulnerable to the antibiotics azithromycin and tetracycline.

McCoy cell monolayer micrograph reveals a number of intracellular Chlamydia trachomatis inclusion bodies; Magnified 200 times. The intracellular inclusion body represents the replication phase of the Chlamydia spp. organisms, whereupon, the reorganised reticulate body multiplies through binary fission into 100-500 new reticulate bodies, which mature into elementary bodies. Eugene Arum/Norman Jacobs/Centers for Disease Control and Prevention/Wikimedia Commons.

Timor-Leste is the 33rd country to eliminate Trachoma as a public health risk, with the other countries being Algeria, Australia, Benin, Burundi, Cambodia, China, Egypt, El Salvador, Fiji, The Gambia, Ghana, India, Iraq, Iran, Laos, Libya, Malawi, Mali, Mauritania, Mexico, Morocco, Myanmar, Nepal, Oman, Pakistan, Papua New Guinea, Saudi Arabia, Senegal, Togo, Tunisia, Vanuatu and Vietnam. Trachoma is one of twenty Neglected Tropical Diseases identified by the World Health Organization's Road Map for Neglected Tropical Diseases 2021–2030, with 68 countries now having eliminated at least one of these diseases. 

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Saturday, 24 April 2021

World Health Organisation confirms The Gambia has eliminated Trachoma as a public health problem.

The World Health Organization has validated The Gambia for having eliminated Trachoma as a public health problem, making it the second country in the World Health Organisation’s African Region to achieve this milestone, according to a press release issued on 20 April 2021. 'This is a great step towards the 2030 goals set by the recently launched 2021–2030 road map for neglected tropical diseases,' said Ren Minghui, the World Health Organisation’s Assistant Director-General for Universal Health Coverage/Communicable and Noncommunicable Diseases. 'Gambia has become the second country this year, after Côte d’Ivoire, to eliminate a neglected tropical disease.'

 
A Gambian mother getting checked for Trachoma. Trachoma is a neglected tropical eye disease. Infection mainly affects children, becoming less common with increasing age. Gambia Eye Health Programm/World Health Organisation.

The Gambia’s success in eliminating Trachoma is largely attributed to strong collaboration with partner organisations to implement the World Health Organisation’s SAFE strategy. 'This is a remarkable achievement that has saved children, mothers and families from preventable visual impairment or blindness, and improved their quality of life and well-being,' said Matshidiso Moeti, the World Health Organisation’s Regional Director for Africa. 'It is also a clear sign that we can achieve significant milestones through dedicated efforts in tackling health challenges in the region.'

At the heart of the efforts against trachoma are Gambian community volunteers, who have played a crucial role in mobilizing communities and promoting behaviour change.

A 2018–2019 survey on Trachomatous Trichiasis (the advanced, blinding stage of trachoma) in Gambia found that the prevalence of this condition among people aged 15 years and above ranged from 0% to 0.02%, well under the threshold required for elimination of Trachoma as a public health problem. This is a huge achievement compared to the mid-1980s, when a national survey estimated that Trachoma was responsible for almost 1 out of 5 cases of blindness, countrywide.

Trachoma is a neglected tropical eye disease. Infection mainly affects children, becoming less common with increasing age. The long-term consequences of infection develop years or even decades later. In adults, women are up to 4 times more likely than men to be affected by the blinding complications of Trachoma, mainly due to their close contact with infected children.

The Gambia and the World Health Organisation will continue to closely monitor previously endemic populations to ensure there is a rapid, proportionate response to any resurgence of the disease. 

Despite The Gambia’s success, Trachoma remains endemic in 27 countries in the World Health Organisation’s African Region, and 29 countries on the African continent overall. Progress against neglected tropical diseases has alleviated the Human and economic burden they impose on the world’s most disadvantaged communities. The 2021–2030 road map for neglected tropical diseases seeks to prevent, control, eliminate or eradicate 20 diseases by 2030.

Globally, Trachoma remains a public health problem in 45 countries, with an estimated 137 million people living in areas endemic for the disease. Significant progress has been made over the past few years, the number of people requiring antibiotic treatment for Trachoma elimination in the African Region fell by 72 million from 189 million in 2014 to 117 million in 2020.

Trachoma is a devastating eye disease caused by infection with the Bacterium Chlamydia trachomatis. The infection spreads from person to person through contaminated fingers, fomites and flies that have come into contact with discharge from the eyes or nose of an infected person.

Environmental risk factors for Trachoma transmission include poor hygiene, overcrowded households, inadequate access to water, and inadequate access to, or use of, proper sanitation facilities.

Repeated infections in childhood lead to scarring of the inner side of the upper eyelids, resulting in inward turning of the eyelid margin, with the lashes touching the globe. This is a painful condition known as Trachomatous Trichiasis, if left untreated, this condition can result in visual impairment and blindness.

In 1996, the World Health Organisation launched the WHO Alliance for the Global Elimination of Trachoma by 2020. With other partners in the Alliance, the World Health Organisation supports country implementation of the SAFE strategy and the strengthening of national capacity through epidemiological assessment, monitoring, surveillance, project evaluation and resource mobilisation.

Elimination of Trachoma is inexpensive, simple and extremely cost-effective, yielding a high rate of net economic return.

Chlamydia trachomatis is a member of the Chlamydiae, a diverse group of Bacteria which are generally pathogenic. Most well understood members of Chlamydiae are intracellular parasites of Animals and single-celled Eukaryotes, and it has long been presumed that these Bacteria were obligate parasites, incapable of living or reproducing outside of Eukarotic cells. However, some free-living species have recently been discovered in deep marine environments, although little is yet known about the life-cycle of these Bacteria.

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