The Ministry of Health of Guinea
has declared the end of the Marburg Virus Disease outbreak in Guéckédou Prefecture, Nzérékoré Region, according to a press release issued by the World Health Organization on 17 September 2021. In accordance with World Health Organization recommendations,
the declaration was made 42 days after the safe and dignified burial of
the only confirmed patient reported in this outbreak. This was the
first-ever Marburg Virus Disease case reported in Guinea.
On 16 September 2021, the Ministry of Health of Guinea
declared the end of the Marburg virus disease outbreak in Guéckédou
prefecture, Nzérékoré Region. In accordance with World Health Organization recommendations,
the declaration was made 42 days after the safe and dignified burial of
the only confirmed patient reported in this outbreak. This was the
first-ever Marburg virus disease case reported in Guinea.
From 3
August 2021 to the end of outbreak declaration, only one confirmed case
was reported. The patient, a man, had onset of symptoms on 25 July. On 1
August he went to a small health facility near his village, with
symptoms of fever, headache, fatigue, abdominal pain and gingival
hemorrhage. A rapid diagnostic test for Malaria returned a negative
result, and the patient received ambulatory supportive care with
rehydration and symptomatic treatment. Upon returning home, his
condition worsened, and he died on 2 August. An alert was subsequently
raised by the sub-prefecture public health care facility to the
prefectorial department of health in Guéckédou. The investigation team
was immediately deployed to the village to conduct an in-depth
investigation and collected a post-mortem oral swab sample, which was
shipped on the same day to the Viral Hemorrhagic Fever Laboratory in
Guéckédou city. On 3 August, the sample tested positive for Marburg Virus Disease by reverse transcriptase-polymerase chain reaction and negative for Ebola Virus Disease. The deceased patient was
buried safely and with dignity on 4 August, with the support of the
national Red Cross.
On
5 August, the National Reference Laboratory in Conakry provided
confirmation by real-time polymerase chain reaction of the positive Marburg result, and on 9
August, the Institut Pasteur Dakar in Senegal provided an additional
confirmation that the result was positive for Marburg Virus Disease and
negative for Ebola Virus Disease.
The Ministry of Health activated the national and district emergency
management committees to coordinate the response and engage with the
community. Additionally, the Ministry of Health together with the World Health Organization, the
United States Centers for Disease Control, the Alliance for International Medical Action, the Red Cross, UNICEF, the International Organization for Migration, and other partners, initiated measures to
control the outbreak and prevent further spread including the
implementation of contact tracing and active case search in health
facilities and at the community level.
During the outbreak, a total of one confirmed case who died, and 173 contacts were identified, including 14 high risk contacts based
on exposure. Among them, 172 were followed for a period of 21 days, of
which none developed symptoms. One high-risk contact was lost to follow
up. At the different points of entry in Guéckédou prefecture where
passengers were screened, no alerts were generated.
Ongoing activities include: Capturing and sampling of Bats in the localities of Temessadou M´Boké,
Baladou Pébal and Koundou to better understand the involvement of Bats
in the ecology of Marburg Viruses; development of a sero-surveillance protocol in the sub-prefecture of Koundou; development and implementation of plans to strengthen Infection
Prevention and Control programmes at the national and facility
level including establishing and mentoring of Infection
Prevention and Control focal persons, Infection
Prevention and Control/hygiene committees, ongoing training of health workers and adequate
procurement and distribution of supplies such as personal protective
equipment; implementation of water, sanitation and hygiene measures with partners including in health facilities and communities; supporting training on community-based surveillance in Guéckédou Prefecture; and risk communication and community mobilization activities in Guéckédou Prefecture as a component of a health emergency preparedness and
response action plan.
A health worker in Gueckedou, Guinea. World Health Organization.
Marburg Virus Disease is an epidemic-prone disease associated with
high case fatality ratios (24-90%). In the early course of the
disease, clinical diagnosis of Marburg Virus Disease is difficult to distinguish from many
other tropical febrile illnesses, because of the similarities in the
clinical symptoms. Other viral hemorrhagic fevers need to be excluded,
particularly Ebola Virus Disease, as well as Malaria, Typhoid Fever, Leptospirosis, Rickettsial infection and Plague. Marburg Virus Disease is
transmitted by direct contact with the blood, bodily fluids and/or
tissues of infected persons or wild Animals (e.g. Monkeys and Fruit Bats).
Investigations are ongoing to identify the source of the infection.
Guinea has previous experience in managing viral hemorrhagic diseases
such as Ebola Virus Disease and Lassa Fever, but this was the first time that Marburg Virus Disease was
reported. The country has a fragile health care system due to the
overburden of disease outbreaks, COVID-19 pandemic, and the recurrent
threat of epidemics such as Malaria, Yellow Fever, Measles, Lassa Fever, Ebola Virus Disease, health care-associated infections, high rates of acute
malnutrition, cyclical natural disasters such as floods, and
socio-political unrest.
Guinea
health authorities responded rapidly to the event, and measures were
rapidly implemented to control the outbreak. Cross-border population
movement and community mixing between Guinea and neighboring Sierra
Leone and Liberia increased the risk of cross-border spread. Sierra
Leone and Liberia health authorities activated contingency plans and
started public health measures at the points of entry with Guinea.
The
affected village is in a remote forest area located at the border with
Sierra Leone, about 9 km from a main international border crossing point
between the two countries. The proximity of the affected area to an
international border, cross-border movement between the affected
district and Sierra Leone, and the potential transmission of the Virus
between Bat colonies and Humans posed an increased risk for cross-border
spread.
These
factors suggested a high risk at the national and regional level, and
given that Guéckédou Prefecture is well connected to Foya District in Liberia,
and Kailahun District in Sierra Leone, this outbreak required an immediate and
coordinated response with support from international partners. The risk
associated with the event at the global level was assessed as low.
Human-to-Human transmission of Marburg virus is primarily associated
with direct contact with blood and/or bodily fluids of infected persons,
and Marburg Virus transmission associated with the provision of health
care has been reported when appropriate infection control measures have
not been implemented.
Health care workers caring for patients with suspected or confirmed
Marburg Virus Disease should apply standard and transmission-based infection prevention and control
precautions to avoid any exposure to blood and/or bodily fluids, as well
as unprotected contact with the possibly contaminated environment. Infection prevention and control
precautions include: Early recognition (screening, triage) and isolation of suspected cases; appropriate isolation capacity (including infrastructure and human resources); health care workers’ access to hand hygiene resources (i.e., soap and water or alcohol-based hand rub); appropriate and accessible personal protective equipment for health care workers; safe infection practices (emphasise on single-use only needles); procedures and resources for decontamination and sterilisation of medical devices; and appropriate management of infectious waste.
Infection prevention and control assessments of health facilities in affected areas using the Infection Prevention and Control
Scorecard revealed sub-optimal results highlighting the need for ongoing
supportive supervision and mentorship for implementation of infection prevention and control in
health care settings in addition to implementing infection prevention and control minimum
requirements to support and strengthen future preparedness for emerging
and re-emerging infectious diseases.
Integrated
disease surveillance and response activities, including community-based
surveillance must continue to be strengthened within all affected
health zones.
Raising
awareness of the risk factors for Marburg Virus Disease and the
protective measures individuals can take to reduce human exposure to the
virus are the key measures to reduce Human infections and deaths. Key
public health communication messages include: Reducing
the risk of Human-to-Human transmission in the community arising from
direct contact with infected patients, particularly with their bodily
fluids; avoiding close physical contact with patients who have Marburg Virus Disease; a ny suspected case ill at home should not be managed at home, but
immediately transferred to a health facility for treatment and
isolation. During this transfer, health care workers should wear
appropriate personal protective eqipment; regular hand washing should be performed after visiting sick relatives in hospital; and communities affected by Marburg should make efforts to ensure that the
population is well informed, both about the nature of the disease itself
to avoid further transmission, community stigmatisation, and encourage
early presentation to treatment centers and other necessary outbreak
containment measures, including safe burial of the dead. People who have
died from Marburg should be promptly and safely buried.
To reduce the risk of wildlife-to-Human transmissions, such as through contact with Fruit Bats, Monkeys, and Apes: Handle wildlife with gloves and other appropriate protective clothing; cook Animal products such as blood and meat thoroughly before consumption and avoid consumption of raw meat; and during work, research activities or tourist visits in mines or caves
inhabited by Fruit Bat colonies, people should wear gloves and other
appropriate protective clothing including masks.
See also...



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